2-Methyl-AP-237: A Dangerous Synthetic Opioid Antagonist
2-methyl-AP-237 powderAlso known as 2-MAP, it is a synthetic opioid that first appeared on the illicit drug market in 2019. It is a derivative of the opioid bucinnazine (AP-237) and has a strong agonistic effect on the u-opioidReceptor Similar to morphine and fentanyl. Although there are no approved medical applications, it has gained importance in recent years in various countries, including Germany.
Chemical structure and properties
The chemical name of 2-methyl-AP-237 is 1-(2-methyl-4-(3-phenylprop-2-en-1-yl)piperazin-1-yl)butan-1-one. In its pure form, it appears as a white, odorless powder. It belongs to the group of acylpiperazine opiates and was originally patented in the 1980s. Although it deviates structurally from fentanyl, it shows similar pharmacological activity.
Pharmacology and potential abuse
Preclinical studies have shown that 2-methyl-AP-237 has a high affinity for the μ-opioid receptor and has a stronger analgesic effect than morphine in animal studies. It has been found to completely replace the discriminatory irritant effects of morphine in rats and is about four times more potent. The effect can be blocked by opioid antagonists such as naloxone. Like other opioids, 2-methyl-AP-237 can lead to rapid development of tolerance and physical dependence.
Illegal distribution and health risks
In the US, 2-methyl-AP-237 was first identified in 2019 in drug sequestrations. Since then, the number of reported cases has increased, with at least ten deaths by the end of 2022. The substance is often offered in capsule form and varies in purity and dosage, which increases the risk of overdoses. In Germany, 2-methyl-AP-237 has also been detected in drug shipments, which is a cause for concern.
Legal classification
Due to its high risk of abuse and associated health risks, 2-methyl-AP-237 has been placed under national narcotics laws in several countries. In Germany, the substance was included in the Narcotics Act in 2019. At international level, it has also been classified as a hazardous substance by the World Health Organization (WHO).
2-Methyl-AP-237 powder is a synthetic opioid with strong potential for abuse and dependence. Although there is no medical license, it has established itself on the illegal drug market and poses a serious threat to public health. The legal measures in various countries underline the need to counter this threat.
Svenja T. (Salzburg, AT) –
I was impressed with the fast shipping and crystal clear structure of the product.
Elias N. (Mainz, DE) –
The product was clean, dry and very fine – perfect for precise laboratory tests. Will be bought again.
Daan J. (Eindhoven, NL) –
Reliable provider for RCs. 2-Methyl-AP-237 showed excellent stability at laboratory temperature.
Nele W. (Antwerp, BE) –
Flawless delivery, well labeled and documented. Perfect for controlled test series.
Clara L. (Frankfurt am Main, DE) –
Very professional provider. The substance was exactly as in the description – perfect for our project.
Ramona B. (Basel, CH) –
Scientifically tested, and delivered exactly what I needed for my experiments.
Valerie S. (Graz, AT) –
Great product! Discreet delivery and fast processing. Ideal for our analytical studies.
Emilia R. (Tilburg, NL) –
All right! Good value for money for such a high quality research substance.
Marcel K. (Osnabrück, DE) –
Quality is excellent. It is easy to solve and shows no deviations.
Julian F. (Dresden, DE) –
Absolutely high-quality research powder. Ordered for the second time – never disappointed.
Martin H. (Bremen, DE) –
Very satisfied with purity and solubility. Came in stable packaging – ideal for our research.
Tobias E. (Innsbruck, AT) –
Super quality and very fine powder. GC-MS analysis confirms the purity of over 99%. Recommendation!
Henrik Z. (Utrecht, NL) –
Purity as described, no residues or foreign substances. Will definitely be ordered again.