O-DSMT (O-desmethyltramadol), O-DSMT
Introduction
O-DSMT, also known as O-desmethyltramadol, is an interesting connection in the field of Research Chemicals. As the main metabolite of tramadol, O-DSMT has attracted the attention of chemists and pharmacologists interested in opioid analogues and laboratory tests. Despite having some similarities with its starting material O-DSMT a unique structure and activity that makes it a valuable research object.
In this article we give an overview of O-DSMT, its chemical properties, laboratory applications and relevance in research.
Chemical profile of O-DSMT
O-DSMT is an synthetic opioid metabolitewhich is derived from tramadol. The IUPAC name is (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanolwhich describes the specific chemical structure.
Important chemical properties:
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Molecular formula: C16H23NO2
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Molecular weight: 261,36 g/mol
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Structure: Contains a phenolic methoxy group and a tertiary amino group enabling unique receptor interactions
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Solubility: Moderately soluble in polar organic solvents
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Stability: Sensitive to strong acids and bases; should be stored under controlled laboratory conditions
The chemical structure of O-DSMT enables Specific interaction with opioid receptors, which allows researchers, Mechanisms and effects of metabolites to investigate more closely.
Laboratory applications
As Research chemicals O-DSMT is mainly Laboratory and pharmacological studies used. Key applications include:
1. Opioid receptor studies
O-DSMT interacts with μ-opioid receptors This makes it ideal for experiments to Receptor binding and activation. Researchers use it to Structure-activity relationships of opioid metabolites, which is valuable for the development of future analgesics.
2. Metabolic and Pharmacokinetic Research
Since O-DSMT is the active metabolite of tramadol, it is used as a model for metabolic studies used. Research priorities are:
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Formation and degradation of metabolites
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Enzymatic activity in liver microsomes
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Pharmacokinetic Properties of Opioid Analogues
Such studies are crucial to Safer and more effective analgesics In a controlled scientific environment.
3. Research on comparative analogues
O-DSMT is used in comparative studies with other Opioid analogues used. Differences in potency, receptor affinity and chemical stability are investigated, providing important insights into Structural activity relationships (SAR) delivers.
4. Analytical chemistry
O-DSMT serves in the Laboratory analysis as a reference substance. Methods such as: HPLC, GC-MS and NMR spectroscopy use O-DSMT to:
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Identify and quantify metabolites
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Validate experimental protocols
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Support research in pharmacy and chemistry
These applications make O-DSMT a valuable tool for Laboratory and pharmacology researchers.
Safety and handling
Although O-DSMT is a research chemical, it should only be used by trained personnel in one Controlled laboratory environment handled. Important security measures:
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Protective equipment: Gloves, laboratory coats, goggles
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Ventilation: Working Under Deduction to Avoid Inhalation
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Storage: Keep cool, dry and dark in sealed containers
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Legal compliance: Observe local regulations on controlled substances and research chemicals
It is important to stress that O-DSMT not for human use is determined. All studies should be exclusively Research-oriented and in compliance with safety and legislation.
Research potential
O-DSMT offers researchers the opportunity to opioid pharmacology without working directly with the starting substance tramadol. Research can help with:
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Analysis of mechanisms of analgesic metabolites
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Investigation of receptor selectivity and binding affinity
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Development of analytical methods for opioid metabolites
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Support for: Drug discovery processes and experimental pharmacology
The investigation of O-DSMT in Controlled laboratory environments Provides valuable insights into Metabolism, receptor interactions and structure-activity relationships and thus contributes to safer and more targeted chemical research.
Conclusion
O-DSMT, or O-desmethyltramadol, is a High quality research chemical with versatile applications in Pharmacology, metabolism research and laboratory analysis. Its unique chemical profile and activity make it an important research object for scientists who are engaged with Opioid analogues and metabolites employ.
For chemists and pharmacologists who are interested in Analytical studies, receptor research and experimental chemistry O-DSMT provides a reliable and informative substance for laboratory work.
Important: O-DSMT should be exclusively Controlled laboratory environment in compliance with the Security and legislation are used. Its value lies in its Research potentialNot in consumption.
