What is 1P-LSD? A researcher’s guide to this psychedelic analogue
With the expansion of psychedelic research, scientists and chemistry enthusiasts alike are turning their attention to 1P-LSD, a potent LSD analogue known for its unique chemical structure and psychoactive potential. Although it shares many similarities with LSD, 1P-LSD possesses special properties that make it interesting for both pharmacological studies and receptor binding assays.
In this guide, we explain the key facts about 1P-LSD—its chemical structure, mechanism of action, research relevance, legal status, and more.
What is 1P-LSD?
1P-LSD stands for 1-propionyl lysergic acid diethylamide, a psychedelic compound structurally similar to LSD (lysergic acid diethylamide). It belongs to the lysergamide family and acts as a prodrug of LSD, meaning it is converted into LSD in the body after ingestion.
Although 1P-LSD was not originally developed for pharmaceutical use, it gained popularity in the early 2010s when it appeared in chemical catalogs and research circles in some jurisdictions as a legal alternative to LSD.
Chemical structure and properties
IUPAC name: (6aR,9R)-N,N-diethyl-7-methyl-4-propionyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Molecular formula: C23H29N3O2
Molecular weight: 379.5 g/mol
Appearance: Usually available as a white powder, blotting paper or solution for research purposes.
The only chemical difference between 1P-LSD and LSD is the propionyl group attached to the nitrogen in position 1 of the indole ring. This modification makes it a prodrug. It is believed that 1P-LSD converts to LSD after metabolism, producing similar psychoactive effects.
Mechanism of action 5-HT2A receptor agonist
1P-LSD is thought to exert its effects primarily through 5-HT2A receptor agonism , similar to LSD. However, it can also interact with other serotonin and dopamine receptors.
Due to its role as a prodrug, most of its pharmacodynamic and pharmacokinetic effects after conversion are attributed to LSD itself. Researchers often use it for the following studies:
- Serotonin receptor binding
- Prodrug metabolic pathways
- Structural activity relationships (SAR) of lysergamides
Research applications
Although it has no approved medical use, 1P-LSD is frequently studied in the following areas:
- Neuropharmacology
- Receptor mapping studies
- Comparative efficacy analysis with other lysergamides
- Cognitive and behavioral model tests in animals Due to its nearly identical effects to LSD, it is a useful analogue when access to LSD is restricted by legal or regulatory restrictions in certain jurisdictions.
Legal status of 1P-LSD
The legality of 1P-LSD varies by country and changes frequently. As of 2025:
- United States: 1P-LSD is not scheduled at the federal level, but may be controlled under the Federal Analog Act.
- United Kingdom: Classified as a Class A drug under the Psychoactive Substances Act.
- Germany: Controlled under the NpSG (New Psychoactive Substances Act).
- Canada and Australia: Often treated as analogues of LSD and therefore regulated.
Important: Always check your local laws before purchasing or using 1P-LSD.
Safety and handling in the laboratory
As with all research chemicals, handling 1P-LSD requires strict precautions in the laboratory:
- Store in a cool, dry and dark place (preferably below 8°C).
- Wear gloves, safety goggles and a fume hood when preparing and transporting samples.
- Accurate weighing with milligram scales.
- Avoid contamination and ensure that all work is carried out in controlled environments.
Final thoughts
1P-LSD is a fascinating compound at the interface of psychedelic chemistry and pharmacology. Its close relationship to LSD makes it an attractive research target, especially in regions with limited access to LSD.
When used responsibly and legally, 1P-LSD offers an effective and valuable tool for researchers seeking to advance their understanding of serotonin agonists, prodrugs, and lysergamide analogues.
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